PDF Reprints, Supporting Materials, Code: requests via email to MG, or check if already posted below (see also Research Gate)


  • Frisari S, Santo M, Hosseini A, Manzati M, Giugliano M, Mallamaci A (2022) Multidimensional Functional Profiling of Human Neuropathogenic FOXG1 Alleles in Primary Cultures of Murine Pallial Precursors, Int. J. Mol. Sci. 23(3), 1343, doi: 10.3390/ijms23031343 PDF


  • George R, Chiappalone M, Giugliano M, Levi T, Vassanelli S, Partzsch J, Mayr C. Plasticity and Adaptation in Neuromorphic Biohybrid Systems. iScience. 2020 Sep 23;23(10):101589. doi: 10.1016/j.isci.2020.101589. eCollection 2020 Oct 23. PMID: 33083749 PMCID: 7554028 PDF
  • Verbist C, Müller MG, Mansvelder HD, Legenstein R, Giugliano M. The location of the axon initial segment affects the bandwidth of spike initiation dynamics. PLoS Comput Biol. 2020 Jul 23;16(7):e1008087. doi: 10.1371/journal.pcbi.1008087. eCollection 2020 Jul. PMID: 32701953 PMCID: 7402515 PDF simulation code
  • Borda Bossana S, Verbist C, Giugliano M. Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons. Front Cell Neurosci. 2020 Jun 17;14:118. doi: 10.3389/fncel.2020.00118. eCollection 2020. PMID: 32625063 PMCID: 7313227 PDF shared data, analysis script, simulation code
  • Manzati M, Sorbo T, Giugliano M, Ballerini L. Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation. Mol Brain. 2020 May 19;13(1):78. doi: 10.1186/s13041-020-00619-z. PMID: 32430072 PMCID: 7236481 PDF
  • Jones PD, Moskalyuk A, Barthold C, Gutöhrlein K, Heusel G, Schröppel B, Samba R, Giugliano M. Low-Impedance 3D PEDOT:PSS Ultramicroelectrodes. Front Neurosci. 2020 May 19;14:405. doi: 10.3389/fnins.2020.00405. eCollection 2020. PMID: 32508562 PMCID: 7248397 PDF
  • Lourenço J, De Stasi AM, Deleuze C, Bigot M, Pazienti A, Aguirre A, Giugliano M, Ostojic S, Bacci A. Modulation of Coordinated Activity across Cortical Layers by Plasticity of Inhibitory Synapses. Cell Rep. 2020 Jan 21;30(3):630-641.e5. doi: 10.1016/j.celrep.2019.12.052. PMID: 31968242 PMCID: 6988114 PDF
  • Moskalyuk A, Van De Vijver S, Verstraelen P, De Vos WH, Kooy RF, Giugliano M. Single-Cell and Neuronal Network Alterations in an In Vitro Model of Fragile X Syndrome. Cereb Cortex. 2020 Jan 10;30(1):31-46. doi: 10.1093/cercor/bhz068. PMID: 30958540 shared data, analysis script, simulation code PDF



  • Pampaloni NP, Giugliano M, Scaini D, Ballerini L, Rauti R. Advances in Nano Neuroscience: From Nanomaterials to Nanotools. Front Neurosci. 2019 Jan 15;12:953. doi: 10.3389/fnins.2018.00953. eCollection 2018. PMID: 30697140 PMCID: 6341218 PDF
  • Goriounova NA, Heyer DB, Wilbers R, Verhoog MB, Giugliano M, Verbist C, Obermayer J, Kerkhofs A, Smeding H, Verberne M, Idema S, Baayen JC, Pieneman AW, de Kock CP, Klein M, Mansvelder HD. Large and fast human pyramidal neurons associate with intelligence. Elife. 2018 Dec 18;7:e41714. doi: 10.7554/eLife.41714. PMID: 30561325 PMCID: 6363383 PDF numerical data table
  • Aydın Ç, Couto J, Giugliano M, Farrow K, Bonin V. Locomotion modulates specific functional cell types in the mouse visual thalamus. Nat Commun. 2018 Nov 19;9(1):4882. doi: 10.1038/s41467-018-06780-3. PMID: 30451819 PMCID: 6242985 PDF
  • Pampaloni NP, Lottner M, Giugliano M, Matruglio A, D'Amico F, Prato M, Garrido JA, Ballerini L, Scaini D. Single-layer graphene modulates neuronal communication and augments membrane ion currents. Nat Nanotechnol. 2018 Aug;13(8):755-764. doi: 10.1038/s41565-018-0163-6. Epub 2018 Jun 11. PMID: 29892019 PDF
  • Espuny-Camacho I, Michelsen KA, Linaro D, Bilheu A, Acosta-Verdugo S, Herpoel A, Giugliano M, Gaillard A, Vanderhaeghen P. Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way. Cell Rep. 2018 May 29;23(9):2732-2743. doi: 10.1016/j.celrep.2018.04.094. PMID: 29847802 PMCID: 5990494 PDF
  • Linaro D, Biró I, Giugliano M. Dynamical response properties of neocortical neurons to conductance-driven time-varying inputs. Eur J Neurosci. 2018 Jan;47(1):17-32. doi: 10.1111/ejn.13761. Epub 2017 Dec 2. PMID: 29068098 PDF shared data set and analysis scripts


  • Bifari F, Decimo I, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P. Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. Cell Stem Cell. 2017 Mar 2;20(3):360-373.e7. doi: 10.1016/j.stem.2016.10.020. Epub 2016 Nov 23. PMID: 27889318 PDF


  • Pulizzi R, Musumeci G, Van den Haute C, Van De Vijver S, Baekelandt V, Giugliano M. Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks. Sci Rep. 2016 Apr 21;6:24701. doi: 10.1038/srep24701. PMID: 27099182 PMCID: 4838830 PDF video seminar
  • Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, Chaze T, Tudor C, Boulegue C, Holt M, Daelemans D, Matondo M, Ghesquière B, Giugliano M, Ruiz de Almodovar C, Dewerchin M, Carmeliet P. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep. 2016 Mar 22;14(11):2653-67. doi: 10.1016/j.celrep.2016.02.047. Epub 2016 Mar 10. PMID: 26972007 PMCID: 4805856 PDF
  • Singam SKR, Motylewski J, Monaco A, Gjorgievska E, Bourgeois E, Nesládek M, Giugliano M, Goovaerts E (2016) Contrast Induced by a Static Magnetic Field for Improved Detection in Nanodiamond Fluorescence Microscopy, Phys. Rev. Applied 6, 064013, doi: 10.1103/PhysRevApplied.6.064013 PDF


  • Gehring TV, Vasilaki E, Giugliano M. Highly scalable parallel processing of extracellular recordings of Multielectrode Arrays. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:4178-81. doi: 10.1109/EMBC.2015.7319315. PMID: 26737215
  • Biró I, Giugliano M. A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology. Front Neuroinform. 2015 Jun 23;9:17. doi: 10.3389/fninf.2015.00017. eCollection 2015. PMID: 26157385 PMCID: 4477165
  • Linaro D, Couto J, Giugliano M. Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond. J Vis Exp. 2015 Jun 24;(100):e52320. doi: 10.3791/52320. PMID: 26132434 PMCID: 4545205
  • Peelaerts W, Bousset L, Van der Perren A, Moskalyuk A, Pulizzi R, Giugliano M, Van den Haute C, Melki R, Baekelandt V. α-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature. 2015 Jun 18;522(7556):340-4. doi: 10.1038/nature14547. Epub 2015 Jun 10. PMID: 26061766
  • Warnaar P, Couto J, Negrello M, Junker M, Smilgin A, Ignashchenkova A, Giugliano M, Thier P, De Schutter E. Duration of Purkinje cell complex spikes increases with their firing frequency. Front Cell Neurosci. 2015 Apr 13;9:122. doi: 10.3389/fncel.2015.00122. eCollection 2015. PMID: 25918500 PMCID: 4394703
  • Monaco AM, Giugliano M. Correction: Carbon-based smart nanomaterials in biomedicine and neuroengineering. Beilstein J Nanotechnol. 2015 Feb 18;6:499. doi: 10.3762/bjnano.6.51. eCollection 2015. PMID: 25821691 PMCID: 4361967
  • Couto J, Linaro D, De Schutter E, Giugliano M. On the firing rate dependency of the phase response curve of rat Purkinje neurons in vitro. PLoS Comput Biol. 2015 Mar 16;11(3):e1004112. doi: 10.1371/journal.pcbi.1004112. eCollection 2015 Mar. PMID: 25775448 PMCID: 4361458 shared figures


  • Esposito U, Giugliano M, Vasilaki E. Adaptation of short-term plasticity parameters via error-driven learning may explain the correlation between activity-dependent synaptic properties, connectivity motifs and target specificity. Front Comput Neurosci. 2015 Jan 29;8:175. doi: 10.3389/fncom.2014.00175. eCollection 2014. PMID: 25688203 PMCID: 4310301
  • Testa-Silva G, Verhoog MB, Linaro D, de Kock CP, Baayen JC, Meredith RM, De Zeeuw CI, Giugliano M, Mansvelder HD. High bandwidth synaptic communication and frequency tracking in human neocortex. PLoS Biol. 2014 Nov 25;12(11):e1002007. doi: 10.1371/journal.pbio.1002007. eCollection 2014 Nov. PMID: 25422947 PMCID: 4244038 shared data set, analysis scripts, simulation code
  • Monaco AM, Giugliano M. Carbon-based smart nanomaterials in biomedicine and neuroengineering. Beilstein J Nanotechnol. 2014 Oct 23;5:1849-63. doi: 10.3762/bjnano.5.196. eCollection 2014. PMID: 25383297 PMCID: 4222354
  • Reinartz S, Biro I, Gal A, Giugliano M, Marom S. Synaptic dynamics contribute to long-term single neuron response fluctuations. Front Neural Circuits. 2014 Jul 1;8:71. doi: 10.3389/fncir.2014.00071. eCollection 2014. PMID: 25071452 PMCID: 4077315
  • Esposito U, Giugliano M, van Rossum M, Vasilaki E. Measuring symmetry, asymmetry and randomness in neural network connectivity. PLoS One. 2014 Jul 9;9(7):e100805. doi: 10.1371/journal.pone.0100805. eCollection 2014. PMID: 25006663 PMCID: 4090069
  • Curtis DJ, Sood A, Phillips TJ, Leinster VH, Nishiguchi A, Coyle C, Lacharme-Lora L, Beaumont O, Kemp H, Goodall R, Cornes L, Giugliano M, Barone RA, Matsusaki M, Akashi M, Tanaka HY, Kano M, McGarvey J, Halemani ND, Simon K, Keehan R, Ind W, Masters T, Grant S, Athwal S, Collett G, Tannetta D, Sargent IL, Scull-Brown E, Liu X, Aquilina K, Cohen N, Lane JD, Thoresen M, Hanley J, Randall A, Case CP. Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions. Exp Neurol. 2014 Nov;261:386-95. doi: 10.1016/j.expneurol.2014.05.003. Epub 2014 May 10. PMID: 24818543
  • Linaro D, Couto J, Giugliano M. Command-line cellular electrophysiology for conventional and real-time closed-loop experiments. J Neurosci Methods. 2014 Jun 15;230:5-19. doi: 10.1016/j.jneumeth.2014.04.003. Epub 2014 Apr 24. PMID: 24769169
  • Mahmud M, Pulizzi R, Vasilaki E, Giugliano M. QSpike tools: a generic framework for parallel batch preprocessing of extracellular neuronal signals recorded by substrate microelectrode arrays. Front Neuroinform. 2014 Mar 19;8:26. doi: 10.3389/fninf.2014.00026. eCollection 2014. PMID: 24678297 PMCID: 3958706
  • Vasilaki E, Giugliano M. Emergence of connectivity motifs in networks of model neurons with short- and long-term plastic synapses. PLoS One. 2014 Jan 15;9(1):e84626. doi: 10.1371/journal.pone.0084626. eCollection 2014. PMID: 24454735 PMCID: 3893143


  • Espuny-Camacho I, Michelsen KA, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, Lambert N, Gaspard N, Péron S, Schiffmann SN, Giugliano M, Gaillard A, Vanderhaeghen P. Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron. 2013 Feb 6;77(3):440-56. doi: 10.1016/j.neuron.2012.12.011. PMID: 23395372
  • Sekar S, Jonckers E, Verhoye M, Willems R, Veraart J, Van Audekerke J, Couto J, Giugliano M, Wuyts K, Dedeurwaerdere S, Sijbers J, Mackie C, Ver Donck L, Steckler T, Van der Linden A. Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI. Psychopharmacology (Berl). 2013 Jun;227(3):479-91. doi: 10.1007/s00213-013-2966-3. Epub 2013 Jan 25. PMID: 23354531


  • Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG. Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. J Neurosci. 2011 Oct 5;31(40):14095-106. doi: 10.1523/JNEUROSCI.1985-11.2011. PMID: 21976494 PMCID: 3204932
  • Testa-Silva G, Loebel A, Giugliano M, de Kock CP, Mansvelder HD, Meredith RM. Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Cereb Cortex. 2012 Jun;22(6):1333-42. doi: 10.1093/cercor/bhr224. Epub 2011 Aug 19. PMID: 21856714 PMCID: 3561643
  • Richmond P, Buesing L, Giugliano M, Vasilaki E. Democratic population decisions result in robust policy-gradient learning: a parametric study with GPU simulations. PLoS One. 2011 May 4;6(5):e18539. doi: 10.1371/journal.pone.0018539. PMID: 21572529 PMCID: 3087717
  • Linaro D, Storace M, Giugliano M. Accurate and fast simulation of channel noise in conductance-based model neurons by diffusion approximation. PLoS Comput Biol. 2011 Mar;7(3):e1001102. doi: 10.1371/journal.pcbi.1001102. Epub 2011 Mar 10. PMID: 21423712 PMCID: 3053314 shared material
  • Fuchsberger K, Le Goff A, Gambazzi L, Toma FM, Goldoni A, Giugliano M, Stelzle M, Prato M. Multiwalled carbon-nanotube-functionalized microelectrode arrays fabricated by microcontact printing: platform for studying chemical and electrical neuronal signaling. Small. 2011 Feb 18;7(4):524-30. doi: 10.1002/smll.201001640. Epub 2011 Jan 18. PMID: 21246714


  • Kunze A, Giugliano M, Valero A, Renaud P. Micropatterning neural cell cultures in 3D with a multi-layered scaffold. Biomaterials. 2011 Mar;32(8):2088-98. doi: 10.1016/j.biomaterials.2010.11.047. Epub 2010 Dec 14. PMID: 21159379
  • Talpalar AE, Giugliano M, Grossman Y. Enduring medial perforant path short-term synaptic depression at high pressure. Front Cell Neurosci. 2010 Oct 15;4:128. doi: 10.3389/fncel.2010.00128. eCollection 2010. PMID: 21048901 PMCID: 2967425
  • Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Long-term depression at parallel fiber to Golgi cell synapses. J Neurophysiol. 2010 Dec;104(6):3413-23. doi: 10.1152/jn.00030.2010. Epub 2010 Sep 22. PMID: 20861429 PMCID: 3007626
  • Gambazzi L, Gokce O, Seredenina T, Katsyuba E, Runne H, Markram H, Giugliano M, Luthi-Carter R. Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments. J Pharmacol Exp Ther. 2010 Oct;335(1):13-22. doi: 10.1124/jpet.110.167551. Epub 2010 Jul 12. PMID: 20624994


  • Sucapane A, Cellot G, Prato M, Giugliano M, Parpura V, Ballerini L. Interactions Between Cultured Neurons and Carbon Nanotubes: A Nanoneuroscience Vignette. J Nanoneurosci. 2009 Jun 1;1(1):10-16. doi: 10.1166/jns.2009.002. PMID: 19865604 PMCID: 2768360
  • Cellot G, Cilia E, Cipollone S, Rancic V, Sucapane A, Giordani S, Gambazzi L, Markram H, Grandolfo M, Scaini D, Gelain F, Casalis L, Prato M, Giugliano M, Ballerini L. Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. Nat Nanotechnol. 2009 Feb;4(2):126-33. doi: 10.1038/nnano.2008.374. Epub 2008 Dec 21. PMID: 19197316
  • Gawad S, Giugliano M, Heuschkel M, Wessling B, Markram H, Schnakenberg U, Renaud P, Morgan H. Substrate arrays of iridium oxide microelectrodes for in vitro neuronal interfacing. Front Neuroeng. 2009 Jan 22;2:1. doi: 10.3389/neuro.16.001.2009. eCollection 2009. PMID: 19194527 PMCID: 2634525
  • Giugliano M. Calcium waves in astrocyte networks: theory and experiments. Front Neurosci. 2009 Sep 15;3(2):160-1. doi: 10.3389/neuro.01.019.2009. eCollection 2009. PMID: 20228859 PMCID: 2751621


  • Giugliano M, La Camera G, Fusi S, Senn W. The response of cortical neurons to in vivo-like input current: theory and experiment: II. Time-varying and spatially distributed inputs. Biol Cybern. 2008 Nov;99(4-5):303-18. doi: 10.1007/s00422-008-0270-9. Epub 2008 Nov 15. PMID: 19011920
  • La Camera G, Giugliano M, Senn W, Fusi S. The response of cortical neurons to in vivo-like input current: theory and experiment : I. Noisy inputs with stationary statistics. Biol Cybern. 2008 Nov;99(4-5):279-301. doi: 10.1007/s00422-008-0272-7. Epub 2008 Nov 5. PMID: 18985378
  • Köndgen H, Geisler C, Fusi S, Wang XJ, Lüscher HR, Giugliano M. The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro. Cereb Cortex. 2008 Sep;18(9):2086-97. doi: 10.1093/cercor/bhm235. Epub 2008 Feb 9. PMID: 18263893 PMCID: 3140196
  • Calì C, Berger TK, Pignatelli M, Carleton A, Markram H, Giugliano M. Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis. J Comput Neurosci. 2008 Jun;24(3):330-45. doi: 10.1007/s10827-007-0058-2. Epub 2007 Nov 28. PMID: 18044016


  • Arsiero M, Lüscher HR, Giugliano M. Real-time closed-loop electrophysiology: towards new frontiers in in vitro investigations in the neurosciences. Arch Ital Biol. 2007 Nov;145(3-4):193-209. PMID: 18075116
  • Mazzatenta A, Giugliano M, Campidelli S, Gambazzi L, Businaro L, Markram H, Prato M, Ballerini L. Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits. J Neurosci. 2007 Jun 27;27(26):6931-6. doi: 10.1523/JNEUROSCI.1051-07.2007. PMID: 17596441 PMCID: 6672220
  • Arsiero M, Lüscher HR, Lundstrom BN, Giugliano M. The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex. J Neurosci. 2007 Mar 21;27(12):3274-84. doi: 10.1523/JNEUROSCI.4937-06.2007. PMID: 17376988 PMCID: 6672485


  • Berger T, Lüscher HR, Giugliano M. Transient rhythmic network activity in the somatosensory cortex evoked by distributed input in vitro. Neuroscience. 2006 Jul 21;140(4):1401-13. doi: 10.1016/j.neuroscience.2006.03.003. Epub 2006 Apr 24. PMID: 16632207


  • Giugliano M, Darbon P, Arsiero M, Lüscher HR, Streit J. Single-neuron discharge properties and network activity in dissociated cultures of neocortex. J Neurophysiol. 2004 Aug;92(2):977-96. doi: 10.1152/jn.00067.2004. Epub 2004 Mar 24. PMID: 15044515


  • Reutimann J, Giugliano M, Fusi S. Event-driven simulation of spiking neurons with stochastic dynamics. Neural Comput. 2003 Apr;15(4):811-30. doi: 10.1162/08997660360581912. PMID: 12689388


  • Giugliano M, Bove M, Grattarola M. Insulin release at the molecular level: metabolic-electrophysiological modeling of the pancreatic beta-cells. IEEE Trans Biomed Eng. 2000 May;47(5):611-23. doi: 10.1109/10.841333. PMID: 10851805
  • Giugliano M. Synthesis of generalized algorithms for the fast computation of synaptic conductances with Markov kinetic models in large network simulations. Neural Comput. 2000 Apr;12(4):903-31. doi: 10.1162/089976600300015646. PMID: 10770837


  • Giugliano M, Bove M, Grattarola M. Activity-driven computational strategies of a dynamically regulated integrate-and-fire model neuron. J Comput Neurosci. 1999 Nov-Dec;7(3):247-54. doi: 10.1023/a:1008979302515. PMID: 10596836
  • Giugliano M, Bove M, Grattarola M. Fast calculation of short-term depressing synaptic conductances. Neural Comput. 1999 Aug 15;11(6):1413-26. doi: 10.1162/089976699300016296. PMID: 10423501


  • Bove M, Martinoia S, Verreschi G, Giugliano M, Grattarola M. Analysis of the signals generated by networks of neurons coupled to planar arrays of microtransducers in simulated experiments. Biosens Bioelectron. 1998 Sep 15;13(6):601-12. doi: 10.1016/s0956-5663(98)00015-3. PMID: 9828355